期刊
SEMINARS IN PERINATOLOGY
卷 38, 期 7, 页码 422-428出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.semperi.2014.08.005
关键词
Kernicterus; Magnetic resonance spectroscopy; Tractography; Myelination
资金
- Children's Hospital of Pittsburgh Foundation-Ian Harrison Family Fund for Neonatal Neurology Research Program
- Mario Lemieux Foundation
- National Institutes of Health, USA [K23NS063371]
Infants with chronic bilirubin encephalopathy often demonstrate abnormal bilateral, symmetric, high-signal intensity on T2-weighted magnetic resonance imaging of the globus pallidus and subthalamic nucleus, consistent with the neuropathology of kernicterus. Early magnetic resonance imaging of at-risk infants, while frequently showing increased T1-signal in these regions, may give false-positive findings due to the presence of myelin in these structures. Advanced magnetic resonance imaging including diffusion-weighted imaging, magnetic resonance spectroscopy, and diffusion tensor imaging with tractography may shed new insights into the pathogenesis of bilirubin-induced brain injury and the neural basis of long-term disability in infants and children with chronic bilirubin encephalopathy. (C) 2014 Elsevier Inc. All rights reserved.
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