Congenital diaphragmatic hernia

Congenital diaphragmatic hernia (CDH) is a congenital anomaly consisting of a posterolateral defect in the diaphragm also known as a Bochdalek hernia It occurs in I in 2000 to 3000 newborns and is associated with a variable degree of pulmonary hypoplasia (PH) and persistent pulmonary hypertension (PPH) Despite remarkable advances in neonatal resuscitation and intensive care and the new postnatal treatment strategies. many newborns with CDH continue to have high rates of mortality and morbidity as the result of severe respiratory failure secondary to PH and PPH The pathogenesis of CDH and associated PH an PPH is poorly understood Herein. we aim to review diaphragm and pulmonary development and curie late this to the abnormalities found in CDH (C) 2010 Elsevier Inc All rights reserved