期刊
SEMINARS IN PEDIATRIC SURGERY
卷 18, 期 4, 页码 196-205出版社
ELSEVIER SCIENCE INC
DOI: 10.1053/j.sempedsurg.2009.07.001
关键词
Neural crest; Hirschsprung's disease; Interstitial cells of Cajal; Motility disorders; Enteric neuron
Motility patterns in the mature intestine require the coordinated interaction of enteric neurons, gastrointestinal smooth muscle, and interstitial cells of Cajal. In Hirschsprung's disease, the aganglionic segment causes functional obstruction, and thus the enteric nervous system (ENS) is essential for gastrointestinal motility after birth. Here we review the development of the ENS. We then focus on motility patterns in the small intestine and colon of fetal mice and larval zebrafish, where recent studies have shown that the first intestinal motility patterns are not neurally mediated. Finally, we review the development of gastrointestinal motility in humans. Crown Copyright (C) 2009 Published by Elsevier Inc. All rights reserved.
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