期刊
SEMINARS IN NEPHROLOGY
卷 33, 期 3, 页码 248-256出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.semnephrol.2013.04.005
关键词
Potassium excretion; potassium balance; potassium adaptation; feedback control; feedforward control
资金
- National Institutes of Health [DK090749]
Extracellular K+ homeostasis has been explained by feedback mechanisms in which changes in extracellular K+ concentration drive renal K+ excretion directly or indirectly via stimulating aldosterone secretion. However, this cannot explain meal-induced kaliuresis, which often occurs without increases in plasma K+ or aldosterone concentrations. Recent studies have produced evidence supporting a feedforward control in which gut sensing of dietary K+ increases renal K+ excretion (and extrarenal K+ uptake) independent of plasma K+ concentrations, namely, a gut factor. This review focuses on these new findings and discusses the role of gut factor in acute and chronic regulation of extracellular K+ as well as in the beneficial effects of high K+ intake on the cardiovascular system. (C) 2013 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据