期刊
SEMINARS IN IMMUNOPATHOLOGY
卷 41, 期 1, 页码 49-58出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00281-018-0703-z
关键词
Cancer immunotherapy; Adoptive cell therapy; Tumor-infiltrating lymphocytes; Chimeric antigen receptor; T cells
Adoptive cell therapy (ACT) utilizing either tumor-infiltrating lymphocyte (TIL)-derived T cells or T cells genetically engineered to express tumor recognizing receptors has emerged as a powerful and potentially curative therapy for several cancers. Many ACT-based therapies have recently entered late-phase clinical testing, with several T cell therapies already achieving regulatory approval for the treatment of patients with B cell malignancies. In this review, we briefly outline the principles of adoptively transferred T cells for the treatment of cancer.
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