期刊
SEMINARS IN IMMUNOPATHOLOGY
卷 34, 期 4, 页码 567-580出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00281-012-0312-1
关键词
Celiac disease; Autoimmune disease; Immune-related disease; Genome-wide association studies; GWAS; Pathway analysis
资金
- Celiac Disease Consortium
- Dutch Government [BSIK03009]
- Netherlands Organization for Scientific Research (NWO, VICI grant) [918.66.620]
- Dutch Digestive Diseases Foundation (MLDS) [WO 11-30]
Celiac disease is characterized by a chronic inflammatory reaction in the intestine and is triggered by gluten, a constituent derived from grains which is present in the common daily diet in the Western world. Despite decades of research, the mechanisms behind celiac disease etiology are still not fully understood, although it is clear that both genetic and environmental factors are involved. To improve the understanding of the disease, the genetic component has been extensively studied by genome-wide association studies. These have uncovered a wealth of information that still needs further investigation to clarify its importance. In this review, we summarize and discuss the results of the genetic studies in celiac disease, focusing on the non-HLA genes. We also present novel approaches to identifying the causal variants in complex susceptibility loci and disease mechanisms.
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