期刊
SEMINARS IN IMMUNOPATHOLOGY
卷 32, 期 2, 页码 127-136出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00281-010-0201-4
关键词
PTPN22; LYP; Pep; Csk; Lck; TCR signaling; Tyrosine phosphatase; Autoimmunity
资金
- NIH [R01AI070544]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI070544] Funding Source: NIH RePORTER
A relatively large number of protein tyrosine phosphatases (PTPs) are known to regulate signaling through the T cell receptor (TCR). Recent human genetics studies have shown that several of these PTPs are encoded by major autoimmunity genes. Here, we will focus on the lymphoid tyrosine phosphatase (LYP), a critical negative modulator of TCR signaling encoded by the PTPN22 gene. The functional analysis of autoimmune-associated PTPN22 genetic variants suggests that genetic variability of TCR signal transduction contributes to the pathogenesis of autoimmunity in humans.
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