期刊
SEMINARS IN IMMUNOPATHOLOGY
卷 32, 期 1, 页码 33-42出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00281-009-0185-0
关键词
IL-17 receptor; Th17; Autoimmunity; IL-17RC; Signal transduction
资金
- University at Buffalo (SUNY) School of Medicine and Biomedical Sciences
- NIH [AR054389]
- Amgen
- Alliance for Lupus Research
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR054389] Funding Source: NIH RePORTER
The interleukin (IL)-17 cytokine family members IL-17A and IL-17F mediate inflammatory activities via the IL-17 receptor (IL-17R) complex, comprised of the IL-17RA and IL-17RC subunits. Proper regulation of the IL-17 signaling axis results in effective host defense against extracellular pathogens, while aberrant signaling can drive autoimmune pathology. Elucidating the molecular mechanisms underlying IL-17 signal transduction can yield an enhanced understanding of inflammatory immune processes and also create an avenue for therapeutic intervention in the treatment of IL-17-dependent diseases. To date, the fundamental signaling mechanisms used by the IL-17R complex are still incompletely defined. While current structure-function studies have primarily focused on the IL-17RA subunit, recent research indicates that the IL-17RC subunit plays a key role in modulating IL-17 responses. This review will examine what is known regarding IL-17RC function and provide a framework for future work on this subunit and its impact on human health.
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