期刊
SEMINARS IN IMMUNOPATHOLOGY
卷 31, 期 3, 页码 359-369出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00281-009-0152-9
关键词
Cytokine; Insulin resistance; Inflammation; Kupffer cell; Steatosis
资金
- FIRST Universita di Milano
- Ricerca corrente Ospedale Maggiore Policlinico
- Centro per lo Studio delle Malattie del Fegato e del Metabolismo
- University of Milan
Alcoholic liver disease and nonalcoholic liver disease represent a leading cause of liver disease and share similar pathogenic mechanisms among which activation of the immune system plays a key role. The main events consist in (a) activation of Kupffer cells via TLR-4 by LPS and fatty acids (b) complement activation (c) increased release of proinflammatory mediators (d) alteration in NK and NKT cell number/activity (e) activation of the adaptive immune system. At the same time, activation of intracellular pro-inflammatory pathways by cytokines and bacterial products, inhibit insulin signaling favoring lipogenesis, metabolic alterations, and cell damage.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据