期刊
SEMINARS IN IMMUNOLOGY
卷 26, 期 2, 页码 145-151出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2014.03.002
关键词
Human; NK cells; infection; cytomegalovirus; NKG2C; HLA
类别
资金
- Plan Nacional de I+D [SAF2010-22153-C03]
- Fundacio La Marato de TV3 [121531]
- REEM (Instituto de Salud Carlos III) [RD12/0032/0016]
- Asociacion Espanola Contra el Cancer (AECC)
Human cytomegalovirus (HCMV) causes a highly prevalent and lifelong infection, with a multifaceted impact in human health. NK cells play an important role in the immune response to HCMV and the virus has reciprocally developed a variety of immune evasion strategies. We originally reported that HCMV infection promotes, to a variable degree in healthy individuals, a redistribution of the NK-cell receptor (NKR) repertoire which persists under steady-state conditions. Its hallmark is an expansion of a mature NK-cell subset displaying high surface levels of the CD94/NKG2C activating receptor, with additional distinctive phenotypic and functional features. Such adaptation of host NK cells to HCMV infection, confirmed in different clinical settings, is particularly magnified in immunocompromised patients and influenced by NKG2C gene copy number. The mechanism(s) underlying the differentiation and proliferation of NKG2C+ NK cells, the basis for the individual differences in the magnitude of their expansion, and their precise role in anti-viral defence remain open issues. Moreover, the possibility that the impact of HCMV infection on the NEC-cell compartment may exert a broader influence on immunity deserves further attention. (c) 2014 Elsevier Ltd. All rights reserved.
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