期刊
SEMINARS IN IMMUNOLOGY
卷 26, 期 2, 页码 152-160出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2014.02.001
关键词
Natural killer cells; Toll-like receptors; Anti-viral response; HIV; HCMV; BCG
类别
资金
- Associazione Italiana Ricerca per la Ricerca sul Cancro (AIRC)
NK cells represent important effectors of the innate immunity in the protection of an individual from microbes. During an NK-mediated anti-microbial response, the final fate (survival or death) of a potential infected target cell depends primarily on the type and the number of receptor/ligand interactions occurring at the effector/target immune synapse. The identification of an array of receptors involved in NK cell triggering has been crucial for a better understanding of the NM cell biology. In this context, NCR play a predominant role in NM cell activation during the process of natural cytotoxicity. Regarding the NK-mediated pathogen recognition and NM cell activation, an emerging concept is represented by the involvement of TLRs and activating KIRs. NM cells express certain TLRs in common with other innate cell types. This would mean that specific TLR ligands are able to promote the simultaneous and synergistic stimulation of these innate cells, providing a coordinated mechanism for regulating the initiation and amplification of immune responses. Evidences have been accumulated indicating that viral infections may have a significant impact on NM cell maturation, promoting the expansion of phenotypically and functionally aberrant NM cell subpopulations. For example, during chronic HIV-infection, an abnormal expansion of a dysfunctional CD56neg NM cell subset has been detected that may explain, at least in part, the defective NM cell-mediated antiviral activity. An analogous imbalance of NM cell subsets has been detected in patients receiving HSCT to cure high risk leukemias and experiencing HCMV infection/reactivation. Remarkably, NM cells developing after CMV reactivation may contain memory-like or long-lived NM cells that could exert a potent anti-leukemia effect. (C) 2014 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据