期刊
SEMINARS IN IMMUNOLOGY
卷 26, 期 4, 页码 303-309出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2014.04.005
关键词
C. elegans; Innate immunity; Host-pathogen interaction; Ancestral immunity
类别
资金
- EMBO long-term fellowship
- Deutsche Forschungsgemeinschaft DFG (CECAD) [SFB 829, KFO 286]
- European Research Council (ERC) [260383]
- FP7-PEOPLE-ITN Marie Curie [316354, 316390, 316964, 239330]
- German-Israeli Foundation [GIF 1104-68.11/2010]
- Deutsche Krebshilfe [109453]
- Bundesministerium fur Bildung und Forschung (BMBFSyBaCol)
The nematode worm Caenorhabditis elegans comprises an ancestral immune system. C elegans recognizes and responds to viral, bacterial, and fungal infections. Components of the RNA interference machinery respond to viral infection, while highly conserved MAPK signaling pathways activate the innate immune response to bacterial infection. C. elegans has been particularly important for exploring the role of innate immunity in organismal stress resistance and the regulation of longevity. Also functions of neuronal sensing of infectious bacteria have recently been uncovered. Studies on nematode immunity can be instructive in exploring innate immune signaling in the absence of specialized immune cells and adaptive immunity. (C) 2014 Elsevier Ltd. All rights reserved.
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