期刊
SEMINARS IN IMMUNOLOGY
卷 26, 期 3, 页码 253-266出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2014.05.004
关键词
NF-kappaB; TNF; CD40; IKK; Signaling; Inflammation
类别
资金
- Columbia University
- NIH [RO1-AI068977, RO1-AI093985]
The NF-kappa B family of inducible transcription factors is activated in response to a variety of stimuli. Amongst the best-characterized inducers of NF-kappa B are members of the TNF family of cytokines. Research on NF-kappa B and TNF have been tightly intertwined for more than 25 years. Perhaps the most compelling examples of the interconnectedness of NF-kappa B and the TNF have come from analysis of knock-out mice that are unable to activate NF-kappa B. Such mice die embryonically, however, deletion of TNF or TNFR1 can rescue the lethality thereby illustrating the important role of NF-kappa B as the key regulator of transcriptional responses to TNF. The physiological connections between NF-kappa B and TNF cytokines are numerous and best explored in articles focusing on a single TNF family member. Instead, in this review, we explore general mechanisms of TNF cytokine signaling, with a focus on the upstream signaling events leading to activation of the so-called canonical and noncanonical NF-kappa B pathways by TNFR1 and CD40, respectively. (C) 2014 Elsevier Ltd. All rights reserved.
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