期刊
SEMINARS IN IMMUNOLOGY
卷 26, 期 3, 页码 203-209出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2014.04.003
关键词
Mycobacterium tuberculosis; Inflammation; Granuloma; Cell death; Immunotherapy
类别
Tumor necrosis factor alpha (TNF-alpha) is a critical immune mediator in protection against and pathology of tuberculosis (TB). TNF-alpha had been found to be associated with TB when it was originally identified as cachexin and until today TB research continues to unveil novel roles of this cytokine of highest relevance for the disease process and for novel intervention strategies. The essentiality of TNF-alpha for containment of active TB is reflected by redundancy of cellular sources of this cytokine, by complexity of mechanisms regulating TNF-alpha abundance and by substantial polyfunctionality of this mediator. The propensity of TNF-alpha to modulate granuloma biogenesis and integrity in TB represents the quintessential process in infection outcome. The TNF-alpha signaling pathway has proved amenable for therapy of autoimmune and other chronic inflammatory noninfectious diseases. Whether or not, and to which extent, host-directed therapies based on this cytokine will reach the patient as adjunct therapy against TB remains to be seen. (C) 2014 Elsevier Ltd. All rights reserved.
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