期刊
SEMINARS IN IMMUNOLOGY
卷 25, 期 1, 页码 65-72出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2013.04.004
关键词
Complement; C5a receptor; Periodontitis; Dysbiosis; Porphyromonas gingivalis
类别
资金
- U.S. National Institutes of Health [DE015254, DE021580, DE021685, AI003040, AI068730, AI072106, AI097805, EY020633, GM097747]
Complement plays a key role in immunity and inflammation through direct effects on immune cells or via crosstalk and regulation of other host signaling pathways. Deregulation of these finely balanced complement activities can link infection to inflammatory tissue damage. Periodontitis is a polymicrobial community-induced chronic inflammatory disease that can destroy the tooth-supporting tissues. In this review, we summarize and discuss evidence that complement is involved in the dysbiotic transformation of the periodontal microbiota and in the inflammatory process that leads to the destruction of periodontal bone. Recent insights into the mechanisms of complement involvement in periodontitis have additionally provided likely targets for therapeutic intervention against this oral disease. (C) 2013 Elsevier Ltd. All rights reserved.
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