期刊
SEMINARS IN IMMUNOLOGY
卷 25, 期 5, 页码 342-351出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2013.09.001
关键词
Segmented Filamentous Bacteria; Intestine; Gut barrier; Immunoglobulin A; Intra-epithelial lymphocytes; TH17 cells
类别
资金
- Institut National Pour la Sante et la Recherche
- Institut National de la Recherche Agronomique
- Universite Paris Descartes
- French National Agency for Research
- Fondation Princesse Grace
- European FP7 TORNADO excellence program
Segmented Filamentous Bacteria (SFB) are present in the gut microbiota of a large number of vertebrate species where they are found intimately attached to the intestinal epithelium. SFB has recently attracted considerable attention due to its outstanding capacity to stimulate innate and adaptive host immune responses without causing pathology. Recent genomic analysis placed SFB between obligate and facultative symbionts, unraveled its highly auxotrophic needs, and provided a rationale for the complex SFB life-style in close contact with the epithelium. Herein, we examine how the SFB life-style may underlie its potent immunostimulatory properties and discuss how the trade-offset up between SFB and its hosts can simultaneously help to establish and maintain the ecological niche of SFB in the intestine and drive the post-natal maturation of the host gut immune barrier. (C) 2013 Elsevier Ltd. All rights reserved.
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