期刊
SEMINARS IN IMMUNOLOGY
卷 24, 期 5, 页码 356-364出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2012.04.009
关键词
Aging; CD8 T cells; Immunity; Infection; Homeostasis
类别
资金
- NIH [AG020719, AG035309, AI081680, N01 AI 00017]
Studies of CD8 T cell responses to vaccination or infection with various pathogens in both animal models and human subjects have revealed a markedly consistent array of age-related defects. In general, recent work shows that aged CD8 T cell responses are decreased in magnitude, and show poor differentiation into effector cells, with a reduced arsenal of effector functions. Here we review potential mechanisms underlying these defects. We specifically address phenotypic and numeric changes to the naive CD8 T cell precursor pool, the impact of persistent viral infection(s) and inflammation, and contributions of the aging environment in which these cells are activated. (C) 2012 Elsevier Ltd. All rights reserved.
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