期刊
SEMINARS IN IMMUNOLOGY
卷 24, 期 6, 页码 399-404出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2012.12.006
关键词
T cells; Metabolism; Regulation; Activation; Differentiation; Memory
类别
资金
- NIAID NIH HHS [R01 AI047891] Funding Source: Medline
As T cells respond to pathogens, they must transition from a quiescent, naive state, to a rapidly proliferating, active effector state, and back again to a quiescent state as they develop into memory cells. Such transitions place unique metabolic demands on the differentiating cells. T cells meet these demands by altering their metabolic profiles, which are, in turn, regulated by distinct signaling cascades and transcriptional programs. Here, we examine the metabolic profiles of T cells during an acute immune response and discuss the signal and transcriptional regulators of these metabolic changes. (C) 2012 Elsevier Ltd. All rights reserved.
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