期刊
SEMINARS IN IMMUNOLOGY
卷 24, 期 1, 页码 36-42出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2011.11.005
关键词
Immunoglobulin A; Host-microbial mutualism; Mucosal CD4 T cell responses
类别
资金
- Swiss National Science Foundation
- Canadian Institute for Health Research
- Crohn's and Colitis Foundation Canada
- Canada Research Chairs program
- Chefarzte of the Inselspital
- Genaxen foundation
The large production of immunoglobulin (Ig)A is energetically costly. The fact that evolution retained this apparent luxury of intestinal class switch recombination to IgA within the human population strongly indicates that there must be a critical specific function of IgA for survival of the species. The function of IgA has been investigated in a series of different models that will be discussed here. While IgA has clear protective functions against toxins or in the context of intestinal viral infections, the function of IgA specific for non-pathogenic commensal bacteria remains unclear. In the context of the current literature we present a hypothesis where secretory IgA integrates as an additional layer of immune function into the continuum of intestinal CD4 T cell responses, to achieve a mutualistic relationship between the intestinal commensal microbiota and the host. (C) 2011 Elsevier Ltd. All rights reserved.
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