期刊
SEMINARS IN IMMUNOLOGY
卷 23, 期 2, 页码 92-98出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2011.01.014
关键词
Rheumatoid arthritis; Autoimmunity; Citrullination; Smoking; HLA; Gene-environment interaction; Anti-CCP
类别
资金
- Swedish Research Council
- The Soderberg Foundations
- The AFA Insurance company
- Swedish Rheumatism Foundation
- Combine program
- EU
This review describes how studies on interactions between genetic variants, and environmental factors, mainly smoking, contribute to the understanding of how autoimmunity to post-translationally (citrullinated) proteins/peptides may occur and potentially contribute to certain subsets of rheumatoid arthritis. A main message is that studies on specific immune mechanisms in a complex and heterogeneous disease like RA should be undertaken with the help of results from genetic epidemiology. By those means, it may be possible to identify subsets of RA in a way that in the end allows development and testing of precise and subset-specific interventions against environment as well as genetically defined molecular pathways, in particular those that regulate specific immune responses. (C) 2011 Published by Elsevier Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据