期刊
SEMINARS IN IMMUNOLOGY
卷 22, 期 4, 页码 193-198出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2010.03.006
关键词
gamma delta T cells; T cell receptor; Thymus
类别
资金
- NIAID NIH HHS [R01 AI044920, R01 AI044920-10] Funding Source: Medline
The gamma delta T lmphocytes are often divided into subsets based upon expression of certain TCR components. This division was initially made because gamma delta T cells residing in particular epithelia were found to show tissue specific differences in their TCRs. Many examples now show that gamma delta T cell subsets also appear to be biased to carry out particular functions. This suggests that particular gamma delta TCR types direct the cells to acquire a certain type of functional programming during thymic development. Here, we describe functionally distinct, TCR-defined gamma delta T cell subsets, and evidence that their functions are predetermined in the thymus. (C) 2010 Elsevier Ltd. All rights reserved.
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