期刊
SEMINARS IN IMMUNOLOGY
卷 22, 期 1, 页码 10-16出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2009.11.004
关键词
RAG1; RAG2; Transposase; Evolution; Adaptive immunity
类别
资金
- National Institute on Aging/National Institutes of Health
The recombination activating genes 1 and 2 (Rag1 and Rag2) encode the key enzyme that is required for the generation of the highly diversified antigen receptor repertoire central to adaptive immunity. The longstanding model proposed that this gene pair was acquired by horizontal gene transfer to explain its abrupt appearance in the vertebrate lineage. The analyses of the enormous amount of sequence data created by many genome sequencing projects now provide the basis for a more refined model as to how this unique gene pair evolved from a selfish DNA transposon into a sophisticated DNA recombinase essential for immunity. Published by Elsevier Ltd.
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