期刊
SEMINARS IN IMMUNOLOGY
卷 22, 期 5, 页码 270-275出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2010.04.016
关键词
Thymus; Early thymus precursor; Human; Intrathymic transfer; Notch; IL-7
类别
资金
- Portuguese Foundation for Science and Technology [SFRH/BD/23553/2005]
- ANRS
- Sidaction
- National Institute of Allergy and Infectious Diseases [R01AI059349]
- AFM
- European Community [LSHC-CT-2005-018914]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI059349] Funding Source: NIH RePORTER
The thymus forms as an alymphoid thymic primordium with T cell differentiation requiring the seeding of this anlage. This review will focus on the characteristics of the hematopoietic progenitors which colonize the thymus and their subsequent commitment/differentiation, both in mice and men. Within the thymus, the interplay between Notch1 and IL-7 signals is crucial for the orchestration of T cell development, but the precise requirements for these factors in murine and human thympoeisis are not synonymous. Recent advances in our understanding of the mechanisms regulating precursor entry and their maintenance in the thymus will also be presented. (C) 2010 Elsevier Ltd. All rights reserved.
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