期刊
SEMINARS IN IMMUNOLOGY
卷 22, 期 4, 页码 222-227出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2010.04.003
关键词
T cell development; T cell lineage commitment; T cell receptor; gamma delta T cells; WNT signaling
类别
资金
- NIH/NCI [CA100382]
The mechanism of T cell precursor commitment to the gamma delta or alpha beta T cell lineage remains unclear. While TCR signal strength has emerged as a key factor in lineage commitment based on TCR transgenic models, the entire TCR repertoire may not possess the same discriminatory power. A counterbalance to the TCR as the lineage determinant is the pre-existing heterogeneity in gene expression among precursors, which suggests that single precursors are unlikely to respond homogeneously to a given instructive signal. (C) 2010 Elsevier Ltd. All rights reserved.
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