期刊
SEMINARS IN IMMUNOLOGY
卷 21, 期 2, 页码 69-77出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2009.02.005
关键词
Costimulation; Memory; CD4+T cells; CD8+T cells; CD28
类别
资金
- NIH [A1 66215]
The activation and expansion of naive T cells require costimulatory signals provided by CD28 and TNF family members. In contrast, for many years it was believed that memory T cells do not require CD28 costimulation for expansion during secondary responses. This was based on in vitro experiments that suggested the re-activation of memory T cells is somewhat independent of costimulation. Recent in vivo evidence, however, has challenged this and shown that both CD4+ and CD8+ memory T cells require CD28 costimulation for maximal expansion and pathogen clearance. This requirement has important implications for host immunity, vaccine development and immunotherapeutics. (C) 2009 Elsevier Ltd. All rights reserved.
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