期刊
SEMINARS IN IMMUNOLOGY
卷 21, 期 3, 页码 164-171出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2009.03.001
关键词
Effector T cells; IL-17; Mucosa; Regulatory T cells; T-H 17 cells
类别
资金
- NIH [AR40072, AR44076, P30 AR053495]
- Rheuminations, Inc.
- Arthritis Foundation
- Connecticut Chapter of the Lupus Foundation of America
CD4(+) T-H 17 cells display a featured role in barrier immunity. This effector population of T cells is important for clearance of microorganisms but can also promote autoimmunity at barrier sites. Recent work has indicated that these effector cells share a pathway with CD4(+) regulatory T cells (T-R cells) that also have a critical function in barrier protection and immune regulation. The development and function of T-H 17 cells, and their relationship with T-R cells are discussed. (C) 2009 Elsevier Ltd. All rights reserved.
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