期刊
SEMINARS IN IMMUNOLOGY
卷 21, 期 5, 页码 265-272出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2009.05.010
关键词
CD40; CD40L; CD154; Dendritic cells
类别
资金
- NIH [DE16381, AI52203]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R37AI044257, R01AI052203] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [R01DE016381] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM037905] Funding Source: NIH RePORTER
In this review, we focus on the function of CD40-CD40L (CD154) interactions in the regulation of dendritic cell (DC)-T cell and DC-B cell crosstalk. In addition, we examine differences and similarities between the CD40 signaling pathway in DCs and other innate immune cell receptors, and how these pathways integrate DC functions. As research into DC vaccines and immunotherapies progresses, further understanding of CD40 and DC function will advance the applicability of DCs in immunotherapy for human diseases. (C) 2009 Elsevier Ltd. All rights reserved.
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