期刊
SEMINARS IN IMMUNOLOGY
卷 21, 期 3, 页码 121-129出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2009.01.002
关键词
Innate immune response; T-cell; Intestine; Human; NK receptor; gamma delta T cell; MAIT; NKT; Intraepithelial lymphocyte
类别
资金
- INSERM
- Universite Paris Descartes
- Agence Nationale pour la Recherche Medicale
- Fondation pour la Recherche Medicale
- Association pour la Recherche contre le Cancer
- la Fondation Princesse Grace
One arm of the gut-associated immune system is represented by a vast collection of T lymphocytes which participate in the subtle interplay between innate and adaptive immune mechanisms and maintain homeostasis at the main body external surface. Mounting data are providing exciting new insight into the innate-like mechanisms which enable intestinal T cells to rapidly sense local conditions and which broaden the spectrum of their functions and regulation at this strategic location. Herein we discuss how innate-like T cell recognition by unconventional T cell subsets and expression of innate NK receptors might modulate immune T cell responses in the human normal or diseased intestine. (C) 2009 Elsevier Ltd. All rights reserved.
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