期刊
SEMINARS IN IMMUNOLOGY
卷 21, 期 6, 页码 318-327出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2009.04.002
关键词
Autoimmunity; Ethnic heterogeneity; Genetic risk; Human leukocyte antigen (HLA); Linkage disequilibrium (LD); Major histocompatibility complex (MHC); Pleiotropy; Psoriasis; Rheumatoid arthritis (RA); Genome-wide association studies
类别
Talk of numerous genetic risk factors for rheumatoid arthritis (RA) and psoriasis has been percolating for years, but with the exception of the human leukocyte antigen (HLA) region, none have been definitively identified. Recently the results of multiple, well powered, genetic case-control studies have begun to appear providing convincing statistical evidence for at least ten non-HLA related risk genes or loci (C5/TRAF1, CD40, CTIA4, KIF5A/PIP4K2C, MMEL1/TNFRSF14, PAD14, PRKCQ, PTPN22, STAT4, and TNFAIP3/OLIG3) for RA and six (IL12B, IL13, IL23R, STAT2/IL23A, TNFAIP3, and TNIP1) for psoriasis. These initial, novel findings are beginning to shed light on the molecular pathways pertinent to the individual diseases and highlight the pleiotropic effects of several risk factors as well as the allelic heterogeneity underlying susceptibility to these and other autoimmune diseases. (C) 2009 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据