期刊
SEMINARS IN IMMUNOLOGY
卷 21, 期 6, 页码 334-345出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2009.10.001
关键词
Inflammatory Bowel disease; Crohn disease; Ulcerative colitis; Nucleotide-binding and oligomerization domain protein 2 (NOD2); Autophagy; Genome-wide association study; Inflammation; Epithelial barrier
类别
资金
- European Commission (READNA)
- Nationales Genomforschungsnetz (NGFN)
- BMBF
- Deutsche Forschungsgemeinschaft (DFG) [SFB415, SCHR512/11-1]
- Clusters of Excellence Future Ocean and inflammation
Recent advances have enabled a comprehensive understanding of the genetic architecture of inflammatory bowel disease (IBD) with over 30 identified and replicated disease loci. The pathophysiological consequences of disease gene variants in Crohn disease and ulcerative colitis, the two main subentities of IBD, so far are only understood on the single disease gene level, yet complex network analyses linking the individual risk factors into a molecular risk map are still missing. In this review, we will focus on recent pathways and cellular functions that emerged from the genetic studies (e.g. innate immunity, autophagy) and delineate the existence of shared (e.g. IL23R, IL12B) and unique (e.g. NOD2 for CD) risk factors for the disease subtypes. Ultimately, the defined molecular profiles may identify individuals at risk early in life and may serve as a guidance to administer personalized interventions for causative therapies and/or early targeted prevention strategies. Due to this comparatively advanced level of molecular understanding in the field, IBD may represent precedent also for future developments of individualized genetic medicine in other polygenic disorders in general. (C) 2009 Elsevier Ltd. All rights reserved.
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