期刊
SEMINARS IN IMMUNOLOGY
卷 20, 期 2, 页码 109-116出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2007.11.003
关键词
extracellular matrix; scaffold; regenerative medicine; remodeling
类别
资金
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR054940] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB000506] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM060691] Funding Source: NIH RePORTER
- NIAMS NIH HHS [R01 AR054940, R01 AR054940-02] Funding Source: Medline
- NIBIB NIH HHS [R01 EB000506, R01 EB000506-04] Funding Source: Medline
- NIGMS NIH HHS [R01 GM060691-02] Funding Source: Medline
Biologic scaffold materials composed of mammalian extracellular matrix are commonly used in regenerative medicine and in surgical procedures for the reconstruction of numerous tissue and organs. These biologic materials are typically allogeneic or xenogeneic in origin and are derived from tissues such as small intestine, urinary bladder, dermis, and pericardium. The innate and acquired host immune response to these biologic materials and the effect of the immune response upon downstream remodeling events has been largely unexplored. Variables that affect the host response include manufacturing processes, the rate of scaffold degradation, and the presence of cross species antigens. This manuscript provides an overview of studies that have evaluated the immune response to biologic scaffold materials and variables that affect this response. (c) 2007 Elsevier Ltd. All rights reserved.
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