Homeostatic chemokines in development, plasticity, and functional organization of the intestinal immune system

In the past decade accumulating evidence supported the view that the immune system should be regarded as trust consisting of several branches. In this review, we will first introduce the architectural features comprising the intestinal immune system emphasising its plasticity and subsequently discuss the concepts describing its development. We then focus on the chemokine/receptor system as a key integrator managing coordinated migration of and communication among the cells mediating intestinal immunity. Thus, chemokines control development and maintain functionality of the intestinal immune system that is required to perform the unique balancing act between tolerating food, cur-tailing commensals activities and eliminating pathogenic infections. (c) 2008 Elsevier Ltd. All rights reserved.