期刊
SEMINARS IN IMMUNOLOGY
卷 20, 期 4, 页码 236-246出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2008.07.006
关键词
T-cell development; lineage commitment; mast cells; dendritic cells; transcription factor
类别
资金
- NIH [CA90233, CA98925, HL089123]
- Albert Billings Ruddock Professorship
- Garfinkle Memorial Laboratory Fund
T-cell precursors remain developmentally plastic for multiple cell generations after entering the thymus, preserving access to developmental alternatives of macrophage, dendritic-cell, and even mast-cell fates. The underlying regulatory basis of this plasticity is that early T-cell differentiation depends on transcription factors which can also promote alternative developmental programs. Interfactor competition, together with environmental signals, keep these diversions under control. Here the pathways leading to several lineage alternatives for early pro-T-cells are reviewed, with close focus on the mechanisms of action of three vital factors, GATA-3, PU.1, and Notch-Delta signals, whose counterbalance appears to be essential for T-cell specification. (C) 2008 Elsevier Ltd. All rights reserved.
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