Avian NK activities, cells and receptors

Natural killer (NK) activity has been examined in birds for over 30 years, but evidence that avian NK activity plays crucial roles in disease is only suggestive. In chickens, NK activity is mediated by TCRO cells in the intestinal epithelium, but elsewhere subsets of alpha beta(3 and gamma delta Tcells (NKT cells) may be more important. There are few lectin-like NK receptor genes, located in the genomic region syntenic with the natural killer complex (NKC) as well as the major histocompatibility complex (MHC). In contrast, a huge number of Ig-like receptor genes are located in a region syntenic with the leukocyte receptor complex (LRC). (C) 2008 Elsevier Ltd. All rights reserved.