期刊
SEMINARS IN DIALYSIS
卷 22, 期 6, 页码 665-670出版社
WILEY
DOI: 10.1111/j.1525-139X.2009.00662.x
关键词
-
资金
- National Institute of Biomedical Imaging and Bioengineering, NIH [1K08 EB003468, 1 R01 EB008049-01]
The confluence of an increasing prevalence of end-stage renal disease (ESRD), clinical trial data suggestive of benefit from quotidian dialysis, and ongoing cost/benefit reanalysis of healthcare spending have stimulated interest in technological improvements in provision of ESRD care. For the last decade, our group has focused on enabling technologies that would permit a paradigm shift in dialysis care similar to that brought by implantable defibrillators to arrhythmia management. Two significant barriers to wearable or implantable dialysis persist: package size of the dialyzer and water requirements for preparation of dialysate. Decades of independent research into highly efficient membranes and cell-based bioreactors culminated in a team effort to develop an implantable version of the University of Michigan Renal Assist Device. In this review, the rationale for the design of the implantable artificial kidney is described.
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