期刊
SEMINARS IN CUTANEOUS MEDICINE AND SURGERY
卷 37, 期 3, 页码 143-147出版社
FRONTLINE MEDICAL COMMUNICATIONS
DOI: 10.12788/j.sder.2018.040
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资金
- Abbvie
- Pfizer
- Novartis
- Leo
- Amgen
- Boehringer Ingelheim Pharma
- Celgene
- Janssen-Cilag
- Lilly
- Xenoport
Ustekinumab is an interleukin-12/23 inhibitor used for the treatment of moderate-to-severe psoriasis. Here, we review new evidence since ustekinumab was licensed for relative efficacy in comparison with other biologic therapies from head-to-head randomized controlled trials and network meta-analyses for the treatment of psoriasis. We also review observational data emerging from psoriasis registries reporting the effectiveness and safety of ustekinumab. Overall, new evidence suggests that ustekinumab has a favorable balance between efficacy/effectiveness, safety, and tolerability and should remain a first-line biologic therapy option for patients with severe psoriasis at present. (C) 2018 Frontline Medical Communications
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