期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 34, 期 -, 页码 109-115出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2014.02.015
关键词
Mitosis; Spindle; Spindle positioning; Spindle formation; Actin; Cortex; Cell shape
资金
- Cancer Research UK Senior Research Fellowship
- Cancer Research UK [9786] Funding Source: researchfish
- Medical Research Council [MC_CF12266] Funding Source: researchfish
Cell division requires the wholesale reorganization of cell architecture. At the same time as the microtubule network is remodelled to generate a bipolar spindle, animal cells entering mitosis replace their interphase actin cytoskeleton with a contractile mitotic actomyosin cortex that is tightly coupled to the plasma membrane - driving mitotic cell rounding. Here, we consider how these two processes are coordinated to couple chromosome segregation and cell division. In doing so we explore the relative roles of cell shape and the actin cortex in spindle morphogenesis, orientation and positioning. (C) 2014 Elsevier Ltd. All rights reserved.
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