期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 34, 期 -, 页码 91-98出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2014.06.019
关键词
Signalling dynamics; Information transmission; Encoding; Decoding; Development; Patterning
资金
- EMBL Interdisciplinary Postdoc Programme under the Marie Curie COFUND Actions [18877]
- Swiss National Science Foundation [PBBSP3_146958]
- Swiss National Science Foundation (SNF) [PBBSP3_146958] Funding Source: Swiss National Science Foundation (SNF)
Encoding information at the level of signal dynamics is characterized by distinct features, such as robustness to noise and high information content. Currently, a growing number of studies are unravelling the functional importance of signalling dynamics at the single cell level. In addition, first insights are emerging into how the principles of dynamic signal encoding apply to a multicellular context, such as development. In this review, we will first discuss general concepts of information transmission via signalling dynamics and recent experimental examples focusing on underlying principles, including the role of intracellular network topologies. How multicellular organisms use temporal modulation of specific signalling pathways, such as signalling gradients or oscillations, to faithfully control cell fate decisions and pattern formation will also be addressed. Finally, we will consider how technical advancements in the detection and perturbation of signalling dynamics contribute to reshaping our understanding of dynamic signalling in developing organisms. (C) 2014 The Authors. Published by Elsevier Ltd.
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