期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 30, 期 -, 页码 165-173出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2014.04.030
关键词
Replication termination; Terminator protein; Crystal structure; Recombination; Replicative aging; Gene silencing
资金
- [5R01GM098013-04]
Replication forks in both prokaryotic and eukaryotic systems pause at random sites due to depletion of dNTP pools, DNA damage, tight binding nonhistone proteins or unusual DNA sequences and/or structures, in a mostly non-polar fashion. However, there is also physiologically programmed replication termination at sequence-specific authentic replication termini. Here, the structure and functions of programined replication termini, their mechanism of action and their diverse physiological functions in prokaryotes and eukaryotes have been reviewed. (C) 2014 Elsevier Ltd. All rights reserved.
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