期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 36, 期 -, 页码 113-120出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2014.08.004
关键词
mTOR; Mammalian target of rapamycin; Ribosomal protein; rRNA; RNA polymerase; Rapamycin; mTOR complex 1; 5'-TOP
资金
- Cancer Research UK
- British Heart Foundation [PG/11/18/28824] Funding Source: researchfish
- Cancer Research UK [13576] Funding Source: researchfish
Ribosome biogenesis is critical for cells to generate the ribosomes they need for protein synthesis in order to survive, grow and proliferate. It is a complex process, involving the coordinated production of four different RNA species and about 80 proteins, as well as their assembly into functional ribosomal subunits. Given its high demand for amino acids and nucleotides, it is also a metabolically expensive process for the cell. The mammalian target of rapamycin complex 1 (mTORC1) is a protein kinases which is activated by nutrients, anabolic hormones and oncogenic signaling pathways. mTORC1 positively regulates several steps in ribosome biogenesis, including ribosomal RNA transcription, the synthesis of ribosomal proteins and other components required for ribosome assembly. mTORC1 can thus coordinate stimuli which promote ribosome production with the various steps involved in this process. Although important advances have been made in our understanding of mTORC1 signaling, major questions remain about the molecular mechanisms by which it regulates ribosome biogenesis. (C) 2014 Elsevier Ltd. All rights reserved.
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