期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 24, 期 3, 页码 200-209出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2012.11.002
关键词
Mouse; Zebrafish; Molecular genetics; Sox2; Wnt; Shh; Notch; Fgf; miR-200
资金
- IBENS
- Rocky Mountain Taste and Smell Center [P30 DC004657]
- NIH/NIDCD [DC008373, DC003947]
- [ANR-09-BLAN-077]
Taste buds are found in a distributed array on the tongue surface, and are innervated by cranial nerves that convey taste information to the brain. For nearly a century, taste buds were thought to be induced by nerves late in embryonic development. However, this view has shifted dramatically. A host of studies now indicate that taste bud development is initiated and proceeds via processes that are nerve-independent, occur long before birth, and governed by cellular and molecular mechanisms intrinsic to the developing tongue. Here we review the state of our understanding of the molecular and cellular regulation of taste bud development, incorporating important new data obtained through the use of two powerful genetic systems, mouse and zebrafish. (C) 2012 Elsevier Ltd. All rights reserved.
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