期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 24, 期 3, 页码 179-189出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2012.10.005
关键词
Semaphorins; Plexins; Tumor; Therapeutics; Angiogenesis; Invasion; Metastasis
资金
- Italian Association for Cancer Research (AIRC) [IG-11598]
- International Association for Cancer Research (AICR-UK) [11-0274]
- Italian Ministry for Research (PRIN Grant)
- Worldwide Cancer Research [11-0274] Funding Source: researchfish
The hallmarks of cancer include multiple alterations in the physiological processes occurring in normal tissues, such as cell proliferation, apoptosis, and restricted cell migration. These aberrant behaviors are due to genetic and epigenetic changes that affect signaling pathways controlling cancer cells, as well as the surrounding normal cells in the tumor microenvironment. Semaphorins and their receptors (mainly plexins and neuropilins) are aberrantly expressed in human tumors, and multiple family members are emerging as pivotal signals deregulated in cancer. Notably, different semaphorins can promote or inhibit tumor progression, depending on the implicated receptor complexes and responsive cell type. The important role of semaphorin signals in the regulation of tumor angiogenesis, invasion and metastasis has initiated multiple experimental approaches aimed at targeting these pathways to inhibit cancer. (C) 2012 Elsevier Ltd. All rights reserved.
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