期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 23, 期 2, 页码 200-205出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2011.12.003
关键词
Next-generation sequencing; RNA-seq; Non-coding RNA; Antisense transcript; Gene regulation
资金
- BBSRC
- Wellcome Trust
- BBSRC [BB/I012451/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/I012451/1] Funding Source: researchfish
- Wellcome Trust [095598/Z/11/Z] Funding Source: researchfish
Long non-coding RNAs (lncRNAs) are emerging as an important class of regulatory transcripts that are implicated in a variety of biological functions. RNA-sequencing, along with other next-generation sequencing-based approaches, enables their study on a genome-wide scale, at maximal resolution, and across multiple conditions. This review discusses how sequencing-based studies are providing global insights into lncRNA transcription, post-transcriptional processing, expression regulation and sites of function. The next few years will deepen our insight into the overall contribution of lncRNAs to genome function and to the information flow from genotype to phenotype. (C) 2011 Elsevier Ltd. All rights reserved.
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