期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 23, 期 2, 页码 145-153出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2011.09.002
关键词
Palmitoylation; GTPase; Isoforms; Organelle; Plasma membrane; Microdomains; Nanoclusters
资金
- NWCRF
- BBSRC
- Wellcome Trust
- NIH [GM066717]
- BBSRC [BB/G018162/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/G018162/1] Funding Source: researchfish
Ras proteins are proto-oncogenes that are frequently mutated in human cancers. Three closely related isoforms, HRAS, KRAS and NRAS, are expressed in all cells and have overlapping but distinctive functions. Recent work has revealed how differences between the Ras isoforms in their trafficking, localization and protein-membrane orientation enable signalling specificity to be determined. We review the various strategies used to characterize compartmentalized Ras localization and signalling. Localization is an important contextual modifier of signalling networks and insights from the Ras system are of widespread relevance for researchers interested in signalling initiated from membranes. (C) 2011 Published by Elsevier Ltd.
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