期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 23, 期 3, 页码 258-268出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2011.10.004
关键词
APOBEC; DNA deaminase; Mutation; Regulation; RNA editing
资金
- Public Health Services [NIDDK DK43739, NIAID AI54369, AI095007, AI58789, NINDS NS067671, NIAID AI076085]
- Air Force Office [F49620]
- Bill and Melinda Gates foundation
- Developmental Center for AIDS [NIAID P30 078498]
- institutional Ruth L. Kirschstein National Research Service Public Health Services [GM068411]
APOBEC1 is a cytidine deaminase that edits messenger RNAs and was the first enzyme in the APOBEC family to be functionally characterized. Under appropriate conditions APOBEC1 also deaminates deoxycytidine in single-stranded DNA (ssDNA). The other ten members of the APOBEC family have not been fully characterized however several have deoxycytidine deaminase activity on ssDNAs. Despite the nucleic acid substrate preferences of different APOBEC proteins, a common feature appears to be their intrinsic ability to bind to RNA as well as to ssDNA. RNA binding to APOBEC proteins together with protein-protein interactions, post-translation modifications and subcellular localization serve as biological modulators controlling the DNA mutagenic activity of these potentially genotoxic proteins. (C) 2011 Elsevier Ltd. All rights reserved.
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