期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 23, 期 4, 页码 458-464出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2012.01.017
关键词
Notch signaling; Tumor suppressor; Oncogene
资金
- National Institutes of Health
- Leukemia and Lymphoma Society
- Dermatology Foundation
- DebRA International
- Skin Foundation
Recent deep sequencing of cancer genomes has produced an explosion of new data implicating Notch signaling in several human cancers. Unlike most other pathways, these data indicate that Notch signaling can be either oncogenic or tumor suppressive, depending on the cellular context. In some instances, these relationships were predicted from mouse models or presaged by developmental roles for Notch, but in other cases were unanticipated. This review discusses the pathogenic and translational significance of these new findings. (C) 2012 Elsevier Ltd. All rights reserved.
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