期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 23, 期 7, 页码 758-767出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2012.04.002
关键词
Aging; Mitochondrial dysfunction; Electron transport supercomplexes
资金
- National Institute on Aging [2R01AG017141-06A2]
- National Center for Complementary and Alternative Medicine [P01AT002034]
Mitochondrial decay plays a central role in the aging process. Although certainly multifactorial in nature, defective operation of the electron transport chain (ETC) constitutes a key mechanism involved in the age-associated loss of mitochondrial energy metabolism. Primarily, mitochondrial dysfunction affects the aging animal by limiting bioenergetic reserve capacity and/or increasing oxidative stress via enhanced electron leakage from the ETC. Even though the important aging characteristics of mitochondrial decay are known, the molecular events underlying inefficient electron flux that ultimately leads to higher superoxide appearance and impaired respiration are not completely understood. This review focuses on the potential role(s) that age-associated destabilization of the macromolecular organization of the ETC (i.e. supercomplexes) may be important for development of the mitochondrial aging phenotype, particularly in post-mitotic tissues. (C) 2012 Published by Elsevier Ltd.
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