期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 23, 期 9, 页码 981-986出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2012.09.010
关键词
Hypertrophic scar; Keloid; Wound healing; Mechanotransduction
资金
- Hagey Family Endowed Fund in Stem Cell Research and Regenerative Medicine
- Armed Forces Institute of Regenerative Medicine (United States Department of Defense)
- Oak Foundation
Recent evidence suggests that mechanical forces can significantly impact the biologic response to injury. Integrated mechanical and chemical signaling networks have been discovered that enable physical cues to regulate disease processes such as pathologic scar formation. Distinct molecular mechanisms control how tensional forces influence wound healing and fibrosis. Conceptual frameworks to understand cutaneous repair have expanded beyond traditional cell-cytokine models to include dynamic interactions driven by mechanical force and the extracellular matrix. Strategies to manipulate these biomechanical signaling networks have tremendous therapeutic potential to reduce scar formation and promote skin regeneration. (c) 2012 Elsevier Ltd. All rights reserved.
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