期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 23, 期 4, 页码 412-418出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2012.03.015
关键词
Cancer; Xenopus laevis; Apoptosis; Caspase-2; Metabolism; Model system
资金
- V Foundation
- American Lebanese Syrian Associated Charities (ALSAC)
Abnormal metabolism and the evasion of apoptosis are both considered hallmarks of cancer. A remarkable biochemical model system, the Xenopus laevis oocyte, exhibits altered metabolism coupled to its apoptotic machinery in a similar fashion to cancer cells. This review considers the theory that these two hallmarks of cancer are coupled in tumor cells and provides strong proof that the Xenopus laevis oocyte system is an appropriate model in which to dissect the biochemical events underlying the connection between the two hallmarks. By further elucidating the mechanisms through which metabolism suppresses apoptotic machinery, we may gain a better understanding about how normal cells transform into cancer cells. (C) 2012 Elsevier Ltd. All rights reserved.
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