期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 23, 期 7, 页码 818-826出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2012.08.001
关键词
Hippo pathway; Stem cells; Yap1; Regeneration; Cancer
资金
- Canadian Institutes of Health Research
- National Institutes of Health
- Stand Up to Cancer Foundation
- Department of Defense
Over the past decade, the Hippo signaling cascade has been linked to organ size regulation in mammals. Indeed, modulation of the Hippo pathway can have potent effects on cellular proliferation and/or apoptosis and a deregulation of the pathway often leads to tumor development. Importantly, emerging evidence indicates that the Hippo pathway can modulate its effects on tissue size by the regulation of stem and progenitor cell activity. This role has recently been associated with the central position of the pathway in sensing spatiotemporal or mechanical cues, and translating them into specific cellular outputs. These results provide an attractive model for how the Hippo cascade might sense and transduce cellular 'neighborhood' cues into activation of tissue-specific stem or progenitors cells. A further understanding of this process could allow the development of new therapies for various degenerative diseases and cancers. Here, we review current and emerging data linking Hippo signaling to progenitor cell function. (C) 2012 Elsevier Ltd. All rights reserved.
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